Conférence LilnCog - Convergence of adenosine and GABA signaling for synapse stabilization during development - Dr Lévi

10h - 12h
Organisateur :Didier Vieau
Lieu :Pôle Recherche - Room 3
Manifestation scientifique

Thursday, October 14th - 10:30 AM

Pôle Recherche - Room 3

During development, synapses are produced in excess Only active synapses capable of releasing the neurotransmitter are maintained The mechanisms by which certain synapses are stabilized or deleted during development are poorly understood This must require a transient detector of presynaptic termination activity and a mechanism that clears the synapse when the detector is not activated We have shown that the A2A adenosine receptor can perform all of these functions at the hippocampal GABAergic synapse The A2A receptor can detect the release of adenosine ATP based on synapse activity Once activated, the A2A receptor triggers an increase in the intracellular level of cyclic AMP by activating adenylyl cyclase, which in turn results in the activation of protein kinase A and stabilization of GABAergic synapses via the recruitment of a molecular scaffolding Failure to activate the A2A receptor prevents activation of this signaling and stabilization of synapses

Invited by Didier Vieau , UMR S 1172, Éq . "Alzheimer & Tauopathies"